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Alzheimer's Disease Variant Portal

Alzheimer's Disease
Variant Portal

Alzheimer’s Disease Variants Portal (ADVP) is a harmonized collection of high-quality and suggestive genetic association findings curated from the literature. This resource allows the public community to easily browse, search and understand Alzheimer’s Disease genetics reported across >80 cohorts and 8 populations.

ADVP aims to answer questions such as:

  • What are the population-specific variants associated with Alzheimer's Disease (AD)?
  • What genes are reported to be associated with AD risk?
  • What genetic variants are reported to be associated with AD endophenotypes and neuropathology?
Association Records
Unique Loci

Distribution of association records by

Study design

  • eQTL908 (12.76%)
  • Disease risk3,299 (46.37%)
  • Endophenotype1,880 (26.42%)
  • Age at onset (AAO) / Survival228 (3.20%)
  • Cross phenotype 760 (10.68%)
  • Pleiotropy 32 (0.45%)
  • Neuropathology4 (0.06%)
  • Cognitive4 (0.06%)


  • Expression897 (12.61%)
  • AD3,522 (49.50%)
  • Cognitive436 (6.13%)
  • Other228 (3.20%)
  • Fluid biomarker1,027 (14.43%)
  • Imaging460 (6.47%)
  • Non-ADRD200 (2.81%)
  • ADRD185 (2.60%)
  • Neuropathology160 (2.25%)


Kuksa PP, Liu C-L, Fu W, Qu L, Zhao Y, Katanic Z, Clark K, Kuzma AB, Ho P-C, Tzeng K-T, Valladares O, Chou S-Y, Naj AC, Schellenberg GD, Wang L-S, Leung YY (2022) Alzheimer’s Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer’s Disease. Journal of Alzheimer’s Disease 1–17.


This project was supported by National Institute on Aging [U24-AG041689; U54-AG052427, U01-AG032984]; Biomarkers Across Neurodegenerative Diseases (BAND 3) (award number 18062), co-funded by Michael J Fox Foundation, Alzheimer's Association, Alzheimer's Research UK and the Weston Brain institute.