Alzheimer's Disease Variant Portal
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(https://...@advp.niagads.org/stats/overall): failed to open stream: HTTP request failed! HTTP/1.0 500 Internal Server Error
Filename: home/index.php
Line Number: 3
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 3
Function: file_get_contents
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Notice
Message: Trying to access array offset on value of type null
Filename: home/index.php
Line Number: 5
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 5
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Notice
Message: Trying to access array offset on value of type null
Filename: home/index.php
Line Number: 5
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 5
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Notice
Message: Trying to access array offset on value of type null
Filename: home/index.php
Line Number: 6
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 6
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Notice
Message: Trying to access array offset on value of type null
Filename: home/index.php
Line Number: 6
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 6
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Notice
Message: Trying to access array offset on value of type null
Filename: home/index.php
Line Number: 7
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 7
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Notice
Message: Trying to access array offset on value of type null
Filename: home/index.php
Line Number: 7
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 7
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(https://...@advp.niagads.org/stats/studydesign): failed to open stream: HTTP request failed! HTTP/1.0 500 Internal Server Error
Filename: home/index.php
Line Number: 11
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 11
Function: file_get_contents
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: Invalid argument supplied for foreach()
Filename: home/index.php
Line Number: 14
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 14
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(https://...@advp.niagads.org/stats/phenotype): failed to open stream: HTTP request failed! HTTP/1.0 500 Internal Server Error
Filename: home/index.php
Line Number: 22
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 22
Function: file_get_contents
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: Invalid argument supplied for foreach()
Filename: home/index.php
Line Number: 25
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 25
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
Alzheimer's Disease
Variant Portal
Alzheimer’s Disease Variants Portal (ADVP) is a harmonized collection of high-quality and suggestive genetic association findings curated from the literature. This resource allows the public community to easily browse, search and understand Alzheimer’s Disease genetics reported across >80 cohorts and 8 populations.
ADVP aims to answer questions such as:
- What are the population-specific variants associated with Alzheimer's Disease (AD)?
- What genes are reported to be associated with AD risk?
- What genetic variants are reported to be associated with AD endophenotypes and neuropathology?
Distribution of association records by
Study design
A PHP Error was encountered
Severity: Warning
Message: Invalid argument supplied for foreach()
Filename: home/index.php
Line Number: 115
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 115
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
Phenotype
A PHP Error was encountered
Severity: Warning
Message: Invalid argument supplied for foreach()
Filename: home/index.php
Line Number: 136
Backtrace:
File: /var/www/ci/CodeIgniter-3.1.10/application/views/home/index.php
Line: 136
Function: _error_handler
File: /var/www/ci/CodeIgniter-3.1.10/application/controllers/Home.php
Line: 18
Function: view
File: /var/www/ci/CodeIgniter-3.1.10/index.php
Line: 315
Function: require_once
Citation
Kuksa PP, Liu C-L, Fu W, Qu L, Zhao Y, Katanic Z, Clark K, Kuzma AB, Ho P-C, Tzeng K-T, Valladares O, Chou S-Y, Naj AC, Schellenberg GD, Wang L-S, Leung YY (2022) Alzheimer’s Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer’s Disease. Journal of Alzheimer’s Disease 1–17. https://doi.org/10.3233/jad-215055
Funding
This project was supported by National Institute on Aging [U24-AG041689; U54-AG052427, U01-AG032984]; Biomarkers Across Neurodegenerative Diseases (BAND 3) (award number 18062), co-funded by Michael J Fox Foundation, Alzheimer's Association, Alzheimer's Research UK and the Weston Brain institute.